Figure 11.3   Quality of EGAD pKa predictions

Adapted from Pokala and Handel 2004. [download data]

Since there are very few values available, lys residues were not considered when assessing the accuracy of our predictions. Due to their much higher intrinsic pKa's, the inclusion of these residues with the far more numerous Asp, Glu, and His data can exaggerate the apparent accuracy.